Assistant boss Pep Lijnders says Liverpool must utilise their "many weapons" to make up for the absence of key players in Wednesday's Carabao Cup semi-final first leg against Fulham.
Defender Trent Alexander-Arnold is out for "a few weeks" with a knee injury.
Forward Mohamed Salah is away with Egypt for the Africa Cup of Nations, while midfielder Wataru Endo is taking part in the Asian Cup with Japan.
"There's no 'irreplaceable'," said Lijnders.
"We have many weapons. We don't rely on one, two or three or four players. We're missing probably four or five core players from our leadership group - Robbo [Andy Robertson], Trent [Alexander-Arnold], Mo [Salah].