The Reds were the last English team to win the trophy, back in 2005, when they beat CSKA Moscow 3-1 after extra-time.
Liverpool went into that clash as Champions League winners and will do so again at Besiktas Park on Wednesday when Jürgen Klopp's men take on Europa League holders Chelsea, now under of the management of Frank Lampard.
It will be the 11th time the clubs have faced off in UEFA competition since first meeting in the Champions League 14 years ago and we've picked out three key battles that could decide this one...
Virgil van Dijk v Olivier Giroud
Liverpool's Player of the Year 2019 made a scoring start to the new season as Virgil van Dijk headed in Liverpool's third goal in the 4-1 Premier League win over Norwich City at Anfield last Friday.