James Milner, Roberto Firmino, Naby Keita and Alex Oxlade-Chamberlain will all leave Liverpool at the end of the season, the club has confirmed.
All four players' contracts expire this summer.
They were all part of the side that won the Champions League in 2019 and Premier League in 2019-20.
A statement from Liverpool said: "All four players will depart with our gratitude and appreciation for the contribution they have made."
The club added that special tributes would be paid to the players in the Reds' final Premier League home game of the season against Aston Villa on Saturday.