Alexander-Arnold has a virus while Matip has a sore knee, meaning both players were not part of the 19-man squad that departed John Lennon Airport for Belgium this afternoon.
Klopp told Liverpoolfc.com onboard the team plane: “Trent is ill and Joel is not ready.
“It is just a little thing which usually settles in the two weeks [Matip] had; it did, but then it came up after the United game and so now we just have to make sure this time it settles finally, that’s all. It is not a massive injury, it’s just a bit annoying for him and he cannot do it [face Genk].