The boss will take charge of his 12th encounter with Everton when the Premier League champions head across Stanley Park on Saturday lunchtime.
The German has secured seven victories over the Reds' local rivals during his five-year reign at the club and is now targeting his second win at Goodison Park.
Asked about the feeling when waking up on derby day, Klopp told Premier League Productions: "Of course it's different but in the end, that's one thing.
"It's what you think in the morning of a derby day but then during the day you have to make sure that you do the right things again because the pure football things are not different to other games.