Having earlier registered an assist, Jota headed home Portugal’s third in their 3-0 win over Azerbaijan shortly before being substituted with 12 minutes to go in Baku.
Mane, meanwhile, notched a late penalty as Senegal beat Congo 3-1.
Elsewhere, Andy Robertson and Virgil van Dijk both captained their countries to success, as Scotland defeated Austria 1-0 and the Netherlands routed Turkey 6-1.