However, the captain is confident that whoever replaces the suspended No.4 in Liverpool’s starting line-up at Anfield will do so adeptly.
An ever-present in the Premier League and Champions League to date this season, Van Dijk will miss the first leg of the Reds’ last-16 tie after accumulating three bookings during the group phase.
And, during Monday’s pre-match press conference, Henderson was asked how keenly the centre-back’s absence will be felt.
“Of course he’s a massive miss, a big miss,” the skipper said.
“I think he’s played every game this season so I think you can see how important he is for us as a team.