Liverpool right-back Trent Alexander-Arnold has not been included in England's matchday squad for Monday's Nations League match against Germany.
Fikayo Tomori, Jarrod Bowen and James Ward-Prowse also miss out.
But Brentford striker Ivan Toney is in line to make his international debut.
Toney, who has scored five goals in the Premier League this season, received his first England call-up this month but was not included for the Italy game.
He has been named in the Three Lions' 23-man squad to face Germany, but Manchester City midfielder Jack Grealish is out through suspension.
The other omissions are squad selections and not due to injury.