Liverpool star Diogo Jota and his younger brother Andre are understood to have been driving in an acid green £180,000 Lamborghini Huracan when they crashed.
The tyre of the supercar is said to have blown out while overtaking another vehicle on the A-52 at Cernadilla near Zamora - just ten miles over the border from Portugal.
The siblings were on a road trip to Santander to catch a ferry to Britain after Diogo was advised not to fly following lung surgery, it was reported in his home country today.
Police are investigating the cause of the fatal crash in the early hours of Thursday morning.