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Elsewhere, Philippe Coutinho, Simon Mignolet, Adam Lallana, Dejan Lovren and Divock Origi come in for their first appearances of the summer.
As at Tranmere Rovers on Wednesday, the Reds will field a team in each half at Wigan.
First-half team: Mignolet, Alexander-Arnold, Matip, Klavan, Flanagan, Henderson, Lallana, Woodburn, Salah, Coutinho, Firmino.
Second-half team: Karius, Gomez, Stewart, Lovren, Milner, Wijnaldum, Grujic, Chirivella, Solanke, Sturridge, Origi.