Chelsea could hand debuts to summer signings such as Nicolas Jackson and Axel Disasi but Christopher Nkunku, who has joined from RB Leipzig, may be out until December with a knee injury.
Wesley Fofana is a long-term absentee after having knee surgery last month.
Fellow defender Benoit Badiashile is recovering from a hamstring issue.
New head coach Mauricio Pochettino has indicated that Kepa Arrizabalaga will keep his place in goal ahead of recent recruit Robert Sanchez.
Dominik Szoboszlai and Alexis Mac Allister are set to make their Liverpool debuts.
Two more midfielders, Thiago Alcantara and Stefan Bajcetic, are likely to miss out through injury.