The Reds head to Home Park tomorrow looking to reach the next stage of the FA Cup at the second attempt, after an initial third-round meeting with the Pilgrims at Anfield earlier this month ended goalless.
When asked if Karius could return to action between the sticks down in Devon after tending goal in the sides' first clash, Klopp replied: "If nothing happens, yes, then Loris [will play]."
The German also spoke about the possibility of yet another young player making the step up from the Academy in Kirkby to the senior squad.
U23s captain Wilson was absent from their narrow defeat to Manchester United on Monday evening, and has recently trained at Melwood under the eye of Klopp and his coaching staff.