Left-back Ricardo Pereira is set to make his first appearance in nine months when Leicester line up against Zorya Luhansk on Thursday.
The Portuguese returns for this Europa League Group G match after recovering from a cruciate ligament injury.
Midfielder Wilfred Ndidi and defender Caglar Soyuncu are also set to start after overcoming their injuries.
"It's a chance to field players making their comebacks, but also some young players," manager Brendan Rodgers said.
Leicester booked their place in the last 32 with a 3-3 draw at Braga last week.
With only top spot left to play for, Rodgers has selected six under-23 players in the squad, including 16-year-old defender Ben Nelson.