With Arsenal the first side already through to the last-16 from the Premier League, Leicester City will be hoping to join the Gunners in progressing from the Champions League group stage.
Claudio Ranieri's team would advance if they win in Copenhagen and can even be sure of top spot with victory if Porto lose against fellow group rivals Club Brugge.
Meanwhile Tottenham Hotspur are also in European action and can give their hopes of reaching the last-16 a significant boost by defeating Bayer Leverkusen at Wembley Stadium.
Follow Sportsmail's coverage of the week's remaining matchday four action from the Champions League.