Manchester United will assess the fitness of Luke Shaw and Anthony Martial, who were substituted with respective groin and head injuries against Watford last weekend.
Henrikh Mkhitaryan is also a doubt and Phil Jones remains out.
Leicester keeper Kasper Schmeichel has overcome concussion but has a muscle strain which could delay his return.
Marcin Wasilewski is banned after his midweek red card against Chelsea, while Nampalys Mendy will not be risked.
MOTD COMMENTATOR'S NOTES
Simon Brotherton: "Three league defeats in a row is almost unthinkable for Jose Mourinho and has only happened once before in his managerial career, but he'll need to find a better formula than the one used at Vicarage Road a week ago to avoid it happening this weekend.