Liverpool captain Jordan Henderson is out because of the groin injury he sustained on international duty, while Mohamed Salah is self-isolating after testing positive for coronavirus.
Trent Alexander-Arnold, Joe Gomez and Virgil van Dijk are also absentees but Fabinho, Thiago Alcantara and Alex Oxlade-Chamberlain could be involved.
Leicester City wing-back Timothy Castagne is available after missing four games with a hamstring injury.
Centre back Wesley Fofana is also fit.
LAWRO'S PREDICTION
Liverpool are short of fit centre-halves and they also need to find a way of dealing with Jamie Vardy's pace.
It may well be that they use Fabinho alongside Joel Matip at the back, if the Brazilian midfielder is fit after his hamstring injury.