Jose Mourinho's side go into the game having crashed out of the EFL Cup at the hands of Bristol City of the Championship, but the Red Devils have won their last two league games.
Meanwhile, the home side have been in great form since Claude Puel became their manager but also suffered a midweek EFL Cup exit, losing on penalties to United's local rivals Manchester City.
Both teams will be keen to secure a win in their final game before Christmas, but who made the cut for both sides? Scroll down to see the line-ups.