Newly-promoted Hull City will be led by caretaker manager Mike Phelan, who took temporary charge after Steve Bruce left in July.
Hull's inactivity in the transfer market leaves Phelan with few options and he could reportedly have just 13 senior players available.
Leicester City have a fully-fit squad for their opening game but defender Robert Huth completes a three-game ban.
Ahmed Musa and Nampalys Mendy could make their Premier League debuts.
MOTD COMMENTATOR'S NOTES
Guy Mowbray: "There can't ever have been a more scrambled preparation for a Premier League season than Hull City's.