The Oakland Raiders have clinched their first winning season since 2002, and perhaps with one more win, could also end a playoff drought that has spanned since that same year.
The Buffalo Bills stand in the way of win #10.
At 6-5, the Bills are in 3rd place of the AFC East and 9th overall in the conference, a few spots outside of a wild card berth. So for both teams, this is a big game.
Injury reports are expansive for both teams, so more than ever, unheralded players will need to step up.
Here are x-factors on offense and defense for both the Raiders and the Bills.