Kentucky vs. Iowa State final odds and prediction

Mar 20, 2026; St. Louis, MO, USA; Kentucky Wildcats head coach Mark Pope looks on against the Santa Clara Broncos during the first half of a first round game of the men's 2026 NCAA Tournament at Enterprise Center. Mandatory Credit: Jeff Curry-Imagn Images | Jeff Curry-Imagn ImagesWhen the opening betting line was announced at -4.5 in favor of Iowa State, many fans wondered if the spread would shift following the news of Joshua Jefferson's ankle injury. As of this writing, it has not moved an inch. The line at FanDuel remains exactly where it started on Friday night.

With the Cyclones' star forward highly unlikely to play, the Wildcats will look to take advantage of the missing frontcourt…