The Royals had grabbed a 3-2 lead, but the White Sox were battling back in the fifth inning. They had runners at first and second with two outs and Jose Abreu, who had already hit the first of his two home runs, stood at the plate and fouled off a pitch with a full count.
On that pitch from Jeremy Guthrie, Royals catcher Salvador Perez noticed something about the runner at second, Geovany Soto.
“He’s just putting his head down and going,” Perez said.
So, Perez gave Guthrie the pickoff signal, and Guthrie move started the rundown that ended the inning.