NFL teams are required to get comfortable with being uncomfortable. It's a way of life. "Next man up" is a mentality because it's a necessity. Systems change, players move on, and life as you know it can change at a moment's notice.
But it's not something the Chiefs offense has dealt with much in recent years. Not like this.
Patrick Mahomes, Tyreek Hill and Travis Kelce have been attached at the hip since the moment Mahomes became the Chiefs' starting quarterback in 2018. Kelce has missed one game since Mahomes took over. Hill has only missed four, all coming early in the 2019 season.