4:25 p.m. ET | CBS
Matchup rating: 98.1 | Spread: KC -3.5 (55.5)
What to watch for: The Chiefs' pass defense may be looking suspect in recent weeks, but the Bucs' defense just gave up a season-high 376 passing yards to the Rams, mainly due to missed tackles and coverage breakdowns. The Buccaneers are also allowing a 69.2% completion percentage against the blitz -- fourth worst in the league -- and getting picked apart in their zone coverages. It could be a long day against the defending Super Bowl champs, although Tampa Bay quarterback Tom Brady has shown that he can bounce back after tough losses.