The Kansas City Chiefs will begin the preseason on Saturday, August 9, facing the Arizona Cardinals at State Farm Stadium in Glendale, Arizona.
As part of its weekly release, the team published its first unofficial depth chart of the season. Remember: the depth chart is unofficial — and subject to change throughout the preseason.
| Pos | First | Second | Third | Fourth |
| WR | Rashee Rice | Hollywood Brown | Skyy Moore | Nikko Remigio |
| - | - | Mac Dalena | Jimmy Holiday | Hal Presley |
| WR | Xavier Worthy | JuJu Smith-Schuster | Tyquan Thornton | Jalen Royals |
| - | - | Jason Brownlee | Elijhah Badger | Key'Shawn Smith |
| LT | Josh Simmons | Wanya Morris | Esa Pole | - |
| LG | Kingsley Suamataia | Mike Caliendo | Dalton Cooper | - |
| C | Creed Humphrey | Hunter Nourzad | Joey Lombard | - |
| RG | Trey Smith | C. |