Happy San Francisco 49ers Week! The Jacksonville Jaguars have played the 49ers six times during the regular season. The 49ers lead the series 4-2, and the Jaguars have lost the last four meetings between the two teams.
Week 1: at Alltel Stadium on September 12, 1999
Final score: 49ers - 3, Jaguars - 41
Attendance: 68,678
Jason Craft, Damon Jones, James Stewart, and Aaron Beasley scored touchdowns. Mark Brunell completed 22 out of 30 attempted passes for 265 yards.