WIN ON FIRST DOWN
Win on first down (offense) and it will negate Buffalo’s pass rush, which has only nine sacks this year but is too talented not to break out soon. Win on first down (defense) and it will put pressure on Bills fill-in quarterback EJ Manuel (above) to throw more often. The Jaguars rank 24th in first down offense (5.02 yards per snap) and 14th in first down defense (5.33).
CHALLENGE THE BACKUPS
Buffalo will be starting Cyrus Kouandijo at right tackle because Seantrel Henderson is out with a concussion and Kraig Urbik is at right guard because John Miller left the team Friday for a family issue.