In Indianapolis, will the Colts have Andrew Luck healthy enough to start the season? Will the team turn to Jacoby Brissett, who learned on the job training while absorbing 52 sacks with a faulty offensive line?
Will Deshaun Watson return to form in Houston and be ready by training camp after tearing his ACL last season? Watson was as dynamic as any rookie to ever play the position. He threw for 1,699 yards, 19 touchdowns and eight interceptions in seven games while completing 61.8 percent of his passes. He also rushed for 269 yards and another two touchdowns.