Coming off a 17-10 win over the Houston Texans, the Jacksonville Jaguars will have a chance to start a winning streak when they face the San Francisco 49ers in Week 4. They're currently a three-point underdog, though, and coming out on top won't be a walk in the park.
After all, the Niners are finding ways to win despite the fact that they've been dealing with injuries across the roster. Early in the season, tight end George Kittle landed on Injured Reserve. Pass rusher Nick Bosa followed suit after Week 3.
But even without Bosa and Kittle, San Francisco is still dangerous.