-The Bills are 3-3 while playing three common opponents with the Jaguars. They both beat Miami and lost to the Patriots. The Bills beat the Colts, the Jaguars lost to them.
-The Bills won the last meeting between the two teams in 2013, 27-20. E.J. Manuel, who will start for injured Tyrod Taylor, started that game as a rookie and completed 17 of 24 passes and two TDs with one interception.
-The Bills are coping with a lot of injuries. Both starting receivers, Sammy Watkins and Percy Harvin, are out. Kyle Williams, one of their best defensive linemen, is also sidelined.