Iowa State may be without two of its top players against one of the top teams in the league.
Wide receiver Allen Lazard and safety Kamari Cotton-Moya are both injured and could miss the game against No. 2 Baylor on Saturday, according to a source.
ISU athletic spokesman Mike Green said both made the trip to Waco, Texas.
The story was first reported by the Des Moines Register.
Lazard leads the Cyclones with 406 receiving yards and three touchdowns. Cotton-Moya is second on the team with 40 tackles. He also has 2.5 tackles for loss.