Amakhosi beat Bucs just a week ago on penalties in the Telkom Knockout Cup quarter-finals, and this time they clash in the PSL.
Chiefs are leading the table, while Pirates are seemingly out of the race already but their fans would love nothing better than denting the hopes of their fierce rivals.
Editors' Picks
The banter between the clubs has already started on social media and we take a look at the best comments.
We start with a rather imaginative video posted on Twitter where a fictional Dr Kaizer Chiefs tends to patients, representing PSL clubs.