The Portuguese league leaders visit opponents who made a surprise run to the Champions League semi-finals last year
Roma play host to Porto at the Stadio Olimpico as both teams aim for the quarter-finals of the Champions League.
The Italian side, who lied sixth in Serie A, qualified by winning three matches in Group G, in which they finished second to Real Madrid but ahead of Czech outfit Viktoria Plzen and CSKA Moscow.
Meanwhile, the Portuguese champions topped Group D, seeing off Schalke into second, Galatasaray into third and Lokomotiv Moscow in fourth.
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Both see this as a winnable tie, but who will prevail?