The Borussia Dortmund man will play no part of this summer's tournament while Manchester United midfielder Bastian Schweinsteiger has been included despite fitness concerns
Germany have left Borussia Dortmund forward Marco Reus out of their final 23-man Euro 2016 squad due to injury.
Joachim Low has trimmed his squad and there is no place for the Borussia Dortmund striker with Karim Bellarabi, Julian Brandt (both Bayer Leverkusen) and Sebastian Rudy (1899 Hoffenheim) also omitted.
The four players have now left the training camp in Switzerland where Germany are currently preparing for Sunday's friendly with Hungary ahead of their Euro 2016 opener against Ukraine.