Juventus are at home to Sampdoria in Andrea Pirlo's first Serie A game as head coach.
Pirlo was appointed as Maurizio Sarri's successor last month and the legendary midfielder will set about trying to mastermind a 10th consecutive Scudetto with a clash against Samp at Allianz Stadium on September 20.
Juve are then away to Roma in a mouth-watering second Serie A match of Italy great Pirlo's reign, and travel to Napoli on matchday three.
Atalanta traveling to Lazio looks to be the standout fixture of the opening matchday, however the encounter between the sides that finished third and fourth respectively last season is likely to be postponed until later in the season.