Supporters' Shield contenders meet as New York City FC hosts FC Dallas, and two of the top teams in the Eastern Conference clash when Toronto FC hosts the New York Red Bulls.
| Friday, Sept. 16 | |||||
| 8:00 | Chicago Fire | - | D.C. United | UniMas | |
| Saturday, Sept. 17 | |||||
| 4:00 | Seattle Sounders | - | Vancouver Whitecaps | MLS Live/TSN1 | |
| 6:00 | Portland Timbers | - | Philadelphia Union | MLS Live | |
| 7:00 | New York City FC | - | FC Dallas | MLS Live | |
| 7:30 | Orlando City | - | Columbus Crew | MLS Live | |
| 7:30 | Montreal Impact | - | New England Revolution | MLS Live | |
| 9:00 | Colorado Rapids | - | San Jose Earthquakes | MLS Live | |
| 9:30 | Real Salt Lake | - | Houston Dynamo | MLS Live | |
All times p.