The Columbus Crew begin life without Kei Kamara against the league-leading Colorado Rapids while FC Dallas hosts the Seattle Sounders in a playoff rematch.
| Friday, May 13 | |||||
| 7:00 | D.C. United | - | New York Red Bulls | UniMas | |
| Saturday, May 14 | |||||
| 5:00 | Montreal Impact | - | Philadelphia Union | TSN4/MLS Live | |
| 7:30 | Toronto FC | - | Vancouver Whitecaps | TSN4/MLS Live | |
| 7:30 | Columbus Crew | - | Colorado Rapids | MLS Live | |
| 7:30 | New England Revolution | - | Chicago Fire | MLS Live | |
| 8:30 | Houston Dynamo | - | Real Salt Lake | MLS Live | |
| 9:00 | FC Dallas | - | Seattle Sounders | MLS Live | |
| Sunday, May 15 | |||||
| 3:30 | Sporting Kansas City | - | Orlando City | ESPN/MLS Live | |
| 7:30 | Portland Timbers | - | New York City FC | FS1/MLS Live | |
All times p.