James Tarkowski will earn his first England cap with a start against Italy on Tuesday.
The Burnley defender begins the match at Wembley against the Azzurri, who are coming off a 2-0 loss to Argentina on Friday.
Elsewhere, Dele Alli remains on the bench for Gareth Southgate's side, who defeated the Netherlands 1-0 in Amsterdam on Friday.
Jamie Vardy gets the nod up top for the Three Lions, with Marcus Rashford dropping to the bench after starting against the Netherlands.
After Jordan Pickford started against the Dutch, Jack Butland gets the call in goal with the Three Lions desperately hoping to sort out their goalkeeping situation before the summer's World Cup in Russia.