Tout Puissant Mazembe were eliminated from the Champions League despite a 1-0 win over Raja Casablanca in Lubumbashi on Saturday.
After losing 2-0 in the away leg in Casablanca last weekend, the result was too much for Mazembe to overturn.
Following a goalless first half at Stade du TP Mazembe, the hosts appeared fired up to turn the affair around when teenage forward Isaac Tshikuna Tshibangu reduced arrears five minutes into the second stanza.
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Veteran playmaker Tresor Mputu played in Tshibangu as it looked as though Mazembe could launch a successful comeback, but the Moroccans held on to a 2-1 aggregate victory.