Sergio Aguero moved clear in third place on Argentina's all-time scoring list before Jorge Sampaoli's side fell apart in the second half.
Alex Iwobi scored twice as Nigeria fought back from 2-0 down against an Argentina side missing Lionel Messi to secure a stunning 4-2 friendly victory in Krasnodar.
Sergio Aguero scored his 36th international goal to move clear in third place on Argentina's all-time scoring list as Jorge Sampaoli's side looked set to prosper despite the absence of Messi, who had returned to Barcelona after featuring in the 1-0 win over Russia on Saturday.
Having drawn level with Hernan Crespo by scoring a late winner against the Russians, Aguero followed up his first international goal since June 2016 by tapping home Argentina's second to back up Ever Banega's free-kick opener.