Santiago Solari is not selecting Isco as he feels the Real Madrid star is yet to regain full fitness after surgery, according to Dani Ceballos.
Isco had appendicitis surgery but was quickly recalled by Julen Lopetegui, starting in a 5-1 Clasico thumping away to Barcelona that proved his final game in charge.
But Solari has not picked Isco since taking over, with the club's former winger leading Madrid to four straight wins during his time as interim coach.
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Solari, who was named Lopetegui's permanent successor on Tuesday after signing a deal to 2021, has said he will not rush "special" Isco back into action.