The Indianapolis Colts entered their must-win game against the San Francisco 49ers down two starting offensive linemen, while a third was playing out of position. A few plays in, they lost breakout center Tanor Bortolini. For most of the game, the only Colts’ lineman playing in his normal spot was left guard Quenton Nelson.
The impact was evident in the running game. The 49ers, who have struggled to stop the run without future Hall of Fame linebacker Fred Warner on the field, held the Colts to just 58 yards on the ground and an anemic 2.9 yards per carry.