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The Colts will likely be down multiple O-Line starters against the Cardinals

The Colts' offensive line is suddenly in a state of flux.

Indianapolis could be down at least two starting offensive linemen for Saturday's Christmas primetime road game against the Arizona Cardinals. Center Ryan Kelly will miss a second straight game following the death of his daughter, and right guard Mark Glowinski could miss after testing positive for COVID-19.

Glowinski went on the Reserve/COVID-19 list Thursday, meaning he's up against the clock in order to test negative ahead of Saturday night's game.

More:Colts are giving Ryan Kelly all the time he needs before returning to football

Additionally, the Colts have ruled out safety Andrew Sendejo, who was not able to clear concussion protocol.