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Opening NFL odds Week 1, 2023 season - Jags favored to defeat Colts in Indy

As of this writing, DraftKings Sportsbook predicts a Colts loss in their season opener at home against the Jacksonville Jaguars (-3.5)

. A 3.5-point line is rather friendly, given that the Jags are preseason favorites to win the division.

Of course, making any prediction at this point in the offseason is purely a dart throw. Things could shift if the Colts’ offense is clicking in the preseason.

Indianapolis’ primary issues were on the offensive side of the ball in 2022. The offensive line was a total disaster. Matt Pryor didn’t work out.