INDIANAPOLIS -- The Indianapolis Colts open the 2021 NFL regular season versus the Seattle Seahawks on Sept. 12 at Lucas Oil Stadium. The Colts finished 2020 with a 12-5 record, tied with the Tennessee Titans atop the AFC South, before losing a wild-card game to the Buffalo Bills.
Injuries were the theme of the Colts' training camp. Carson Wentz, Quenton Nelson and Darius Leonard all missed time during with lower leg injuries. But they're all back and heading in the right direction to be on the field for their Week 1 game against the Seattle in Week 1.