INDIANAPOLIS — For the first time in three years and only the second time in the last five, the Colts will open the 2021 season at home in Lucas Oil Stadium.
And it’s a high-profile matchup.
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The Colts will open the 2021 season at 1 p.m. on Sept. 12 against Russell Wilson and the Seattle Seahawks on FOX, the network announced in a morning reveal by Jimmy Johnson.