The Indianapolis Colts (+7.5)
(1-1) travel to take on the undefeated Baltimore Ravens (-7.5) (2-0). The Colts already know the team will be short-handed offensively, as both starting rookie quarterback Anthony Richardson and former Pro Bowl center Ryan Kelly are out with concussions. Once again, that means veteran backup Gardner Minshew will be called upon in relief of Richardson for the third consecutive game—only this time as a starter. Meanwhile, Wesley French will get the start at center, replacing Kelly.
The Ravens are led by dynamic starting quarterback and former NFL MVP Lamar Jackson, who stresses defenses out with both his arm and legs.