The Colts (3-5) reunite against a familiar face, former head coach Frank Reich and his Carolina Panthers (+1.5)
(1-6), coming off their first win of the season.
While this matchup at one time looked like it would feature top pick Bryce Young against #4 overall pick Anthony Richardson at starting quarterback respectively, that of course has since changed. Instead, with Richardson out for the season, it will once again be veteran gunslinger Gardner Minshew behind center for Indianapolis.
For the Colts, establishing the run with Jonathan Taylor and Zack Moss will once again be key, as will generating enough pass pressure defensively on Young to protect a suspect secondary at starting outside cornerback.