4:25 p.m. ET | CBS
Matchup rating: 38.0 | Spread: IND -14 (49.5)
What to watch for: How will the Colts' offensive tackles match up against the Jaguars' pass-rushers? Yes, the Colts will have starting right tackle Braden Smith (reserve/COVID-19 list) back for the game, but there's still a gigantic hole on the left side after the losses of veteran Anthony Castonzo (ankle) and backup Will Holden (ankle). Indianapolis gave up a season-high five sacks against Pittsburgh in Week 16.