The Indianapolis Colts' defense has been able to survive so far without slot corner Kenny Moore II. Moore is one of the best players at his position in the NFL, but Indy has played a couple of teams with dud offenses. That is unlikely to change in Week 6.
The Arizona Cardinals, even if quarterback Kyler Murray plays (he is questionable with a foot injury), haven't been explosive or productive this season. Murray can run around the pocket extremely well, but he seems incapable of consistently leading his team to loads of points.
Indianapolis' Moore won't face Murray and the Cardinals, though, as he has been ruled out for the third straight game with an Achilles injury.