The are headed to Florida in week six to take on the . This marks the second meeting for these teams in 2023 as the Colts see their forth divisional opponent over the first six weeks of the season. The Jaguars have been in total control of this series when it shifts to Jacksonville, winning eight straight contests at TIAA Bank Field against the Colts. DraftKings Sportsbooks sees this one as competitive but gives the Jaguars the upper hand at 4.5 points.
The money line sits at +180 for the Colts with the over/under at 45.